Availability: In StockBiological Description:(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin; apoptosis inducer.IC50 value:Target: apoptosis inducer(20S)-Protopanaxadiol was used to induce cytotoxicity for two human glioma cell lines, SF188 and U87MG. For the SF188 cells, (20S)-Protopanaxadiol activated caspases-3, -8, -7, and -9 within 3 h and induced rapid apoptosis, which could be partially inhibited by a general caspase blocker and completely abolished when the caspase blocker was used in combination with an antioxidant. (20S)-Protopanaxadiol also induced cell death in U87MG cells but did not activate any caspases in these cells [1]. aPPD was able to inhibit P-gp activity as potently as verapamil on MDR cells. The blockage of P-gp activity was highly reversible as wash-out of aPPD resulted in an immediate recovery of P-gp activity. Unlike verapamil, aPPD did not affect ATPase activity of P-gp suggesting a different mechanism of action [2].Purity: >98%Molecular formula: C₃₀H₅₂O₃Molecular Weight: 460.73Storage Instructions: Two years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSOReferences: for more information, please visit images/AffixScientific/

Affix Scientific633克朗

CAS号：286370-15-8

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 1克$ 1650

价格：            $ 1650.00

数量：

1

库存：有存货

目录号 286370-15-8

生物学描述：

KRN633是一种有效的选择性VEGFR抑制剂。抑制人脐静脉内皮细胞中VEGFR-2的酪氨酸磷酸化（IC50 = 1.16 nmol / L）。用重组酪氨酸激酶进行的选择性分析表明，KRN633对VEGFR-1，-2和-3具有高度选择性。在无胸腺小鼠和大鼠中，KRN633在几种具有不同组织起源的体内肿瘤异种移植模型（包括肺，结肠和前列腺）中抑制肿瘤生长。KRN633还可以使一些公认的肿瘤以及那些在停止治疗后已长出的肿瘤消退。KRN633具有良好的耐受性，对动物的体重或总体健康没有明显影响。KRN633可用于治疗实体瘤和其他依赖病理性血管生成的疾病。

纯度： > 98.00％

分子式： C 2 0 H 2 1 ClN 4 O 4  

分子量： 446.90

储存说明：两年-20°C粉末，2周DMSO中4°C，DMSO中6个月-80°C